The P2S handles everything most users will ever need: PLA, PETG, ABS, ASA, TPU, and even PA. The H2S adds active chamber heating and 350°C nozzle capability for materials that truly demand it, such as PPS and fiber-filled PPS, which Bambu does not list for the P2S.
The 1,000 mm/s speed on the H2S sounds impressive, but real-world print times aren't 1.7x faster than on the P2S (1,000 mm/s vs 600 mm/s), most of the speed advantage is seen in infill and travel moves. For detailed prints, both machines operate at similar effective speeds.